塔望科技提供全系列的動物實驗用低/高氧控制產品，包括恒定濃度控制的低氧動物箱、高氧動物箱、可編程的間歇氧濃度控制系統、帶緩沖閘的低氧箱等。整套低氧/高氧實驗箱裝置主要由氧氣控制器和動物實驗箱兩部分組成。另可提供多種不同的氣體控制器，滿足不同實驗O2、CO2、NO、CO、O3等氣體濃度控制的需求。

ProOx-100 編程式間歇氧濃度實驗系統為動物低氧、高氧實驗模型的建立提供合適的氧氣環境，可用于模擬生物體內的生理性低氧狀態，使體外研究結果更接近于體內的真實水平；或用于模擬生物體處于的特殊低氧/高氧時的病理狀態，以便進行相關機理及疾病的研究。可以進行編程式的間歇低氧高氧濃度控制，實現低氧高氧交替實驗。

產品特點及參數：

1. 為動物低氧、高氧實驗模型的建立提供合適的氣體環境

2. 按照設定氣體濃度自動配比氣體，維持恒定的氧氣濃度環境。無需在箱體外混合比例氣體，確保實驗氧濃度的穩定，節省氣源

3. 動態可編程控制的氧濃度實驗箱，實現高氧、缺氧間歇交替控制

4. 采用進口透明聚丙烯酸甲酯板（PMMA）材質，堅固耐用

5. 7英寸大屏觸摸屏控制，人性化界面，操作簡單。

6. 監測參數：溫度、濕度、氧氣O2濃度。

7. 非色散紅外（NDIR）二氧化碳傳感器，測量范圍：0～5000ppm測量精度：±30ppm

8. 進口電化學氧氣O2濃度檢測器，測量范圍：0-100%vol，測量分辨率：0.01%，線性度好，檢測準確、使用壽命長。具有溫度補償機制。

9. 溫度檢測：進口高精度數字鉑電阻溫度傳感器

10. 氧氣濃度變化動態曲線，直觀了解氧氣濃度變化的過程

11. 氧氣濃度自動校準：通過上位機程序對傳感器快速校準

12. 濕度傳感器和除濕設計，能有效的降低動物實驗過程中呼吸產生的水汽對動物的影響。

13. 氣體混合及循環機制，保證箱體內氣體濃度的均一。

14. 高性能電磁閥，性能穩定，超長壽命＞1000萬次

可進行以急性高氧實驗、急性缺氧實驗、慢性缺氧實驗、高氧/低氧交替實驗

ProOx-100 編程式間歇氧濃度實驗系統應用領域

1.基因表達研究：有研究表明，基因組中5%的基因表達是受氧氣濃度調控的；

2.腫瘤生物學：迅速增殖的腫瘤內部的細胞，常處于低氧微環境中；

3.神經生物學：低氧狀態下神經細胞的增殖、分化及損傷研究；

4.睡眠呼吸暫停綜合癥、心肌缺血缺氧、腦缺血損傷、肺動脈高壓、高原反應、腫瘤、眼科疾病、呼吸疾病、造血功能等多種領域的動物建模研究。

我公司可以根據客戶的特殊應用、特殊需求提供功能定制服務，也可以提供相關的實驗服務。

相關文獻

[1]Ma Jinqiu,Wang Chenyun,Sun Yunbo,Pang Lulu,Zhu Siqing,Liu Yijing,Zhu Lin,Zhang Shouguo,Wang Lin,Du Lina. "Comparative study of oral and intranasal puerarin for prevention of brain injury induced by acute high-altitude hypoxia" . [J] International Journal of Pharmaceutics,2020,591

?[2]Guijuan Chen,Kang Cheng,Yun Niu,Li Zhu,Xueting Wang."Epicatechin gallate prevents inflammatory response in hypoxia-activated microglia and cerebral edema by inhibiting NF-κB signaling" . [J]. Archives of Biochemistry and Biophysics ,Volume 729, 109393;

[3]Yapeng,LuPanpanChang,WangwangDing,JiangpeiBian,DanWang,XuetingWang,QianqianLuo,XiaomeiWu,LiZhu."Pharmacological inhibition of mitochondrial division attenuates simulated high-altitude exposure-induced cerebral edema in mice: Involvement of inhibition of the NF-κB signaling pathway in glial cells". [J]. European Journal of Pharmacology,Volume 929,2022,175137

[4]Jun-Yu Wei, Miao-Yue Hu, Xiu-Qi Chen, Feng-Ying Lei, Jin-Shuang Wei, Jie Chen, Xuan-Kai Qin & Yuan-Han Qin ."Rosiglitazone attenuates hypoxia-induced renal cell apoptosis by inhibiting NF-κB signaling pathway in a PPARγ-dependent manner" . [J]. European Journal of Pharmacology,Renal Failure, 44:1, 2056-2065

[5]Yilan Wang, Zherui Shen, Caixia Pei, Sijing Zhao, Nan Jia, Demei Huang, Xiaomin Wang, Yongcan Wu, Shihua Shi, Yacong He, Zhenxing Wang,"Eleutheroside B ameliorated high altitude pulmonary edema by attenuating ferroptosis and necroptosis through Nrf2-antioxidant response signaling" . [J]. Biomedicine & Pharmacotherapy, Volume 156, 2022,113982

[6]Fang Zhao, Yan Meng, Yue Wang, Siqi Fan, Yu Liu,Xiangfeng Zhang, Chenyang Ran, Hongxin Wang and Meili Lu. "Protective effect of Astragaloside IV on chronic intermittent hypoxia-induced vascular endothelial dysfunction through the calpain-1/SIRT1/AMPK signaling pathway" . [J]. Frontiers in Pharmacology,10.3389/fphar.2022.920977

[7]Xu Y, Kong X, Li J, Cui T, Wei Y, Xu J, Zhu Y , Zhu X. “Mild Hypoxia Enhances the Expression of HIF and VEGF and Triggers the Response to Injury in Rat Kidneys." [J]. Front. Physiol. 12:690496. doi: 10.3389/fphys.2021.690496

[8]Liang Xie, Qinhan Wu, Weiping Hu, Xu Wu, Guiling Xiang, Shengyu Hao, Han Guo, Shanqun Li. “Impact of histaminergic H3 receptor antagonist on hypoglossal nucleus in chronic intermittent hypoxia conditions." [J]. Psychopharmacology. 

[9]Li Huang, Tianyou Li, Min Zhou, Mengyan Deng, Lidong Zhang, Long Yi, Jundong Zhu, Xiaohui Zhu, Mantian Mi. “Hypoxia Improves Endurance Performance by Enhancing Short Chain Fatty Acids Production via Gut Microbiota Remodeling." [J]. Front. Microbiol. 12:820691

[10]Yanhong Pei a b, Lifei Huang c, Tong Wang c, Qinhan Yao a, Yanrong Sun a, Yan Zhang a, Xiaomei Yang a, Jiliang Zhai d, Lihua Qin a, Jiajia Xue c, Xing Wang c, Hongquan Zhang a b, Junhao Yan."Bone marrow mesenchymal stem cells loaded into hydrogel/nanofiber composite scaffolds ameliorate ischemic brain injury. materialstoday ADVANCES, Volume 17, March 2023, 100349.

[11]Zhang, C., Sun, Y., Guo, Y. et al. “JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension. “[J].Cell Death Discov. 9, 98 (2023).

[12]Chenyu Xu, Jun Xu, Chunfang Zou, Qian Li, Shan Mao, Ying Shi, Yan Tan, Wei Gu, Liang Ye. "Chronic Intermittent Hypoxia Regulates CaMKII-Dependent MAPK Signaling to Promote the Initiation of Abdominal Aortic Aneurysm."  [J]. Hindawi, Oxidative Medicine and Cellular Longevity Volume 2021, Article ID 2502324, 15 pages

[13]Jing Zhang, Jian-Zhong Jiang, Jun Xu, Chen-Yu Xu, Shan Mao, Ying Shi, Wei Gu, Chun-Fang Zou, Yue-Ming Zhao,  Liang Ye. "Identification of Novel Biomarkers for Abdominal Aortic Aneurysm Promoted by Obstructive Sleep Apnea." [J].  Elsevier Inc. This is an open access article under the CC BY-NC-ND license

[14]Zhang Q, Xu L, Bai Y, Chen P, Xing M, Cai F, Wu Y,  Song W. “Intermittent hypoxia-induced enhancement of sociability and working memory associates with CNTNAP2 upregulation." [J]. Front. Mol. Neurosci. 16:1155047.

[15]Chen Zhang, Yue Sun, Yingying Guo, Jingjing Xu, Haiyan Zhao. “JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension." [J]. Cell Death Discovery (2023) 9:98.

MFN2-mediated mitochondrial fusion facilitates acute hypobaric hypoxia-induced cardiac dysfunction by increasing glucose catabolism and ROS production,Biochimica et Biophysica Acta (BBA) - General Subjects,Volume 1867, Issue 9,2023,130413,ISSN 0304-4165

[17]Eleutheroside E from pre-treatment of Acanthopanax senticosus (Rupr. etMaxim.) Harms ameliorates high-altitude-induced heart injury by regulating NLRP3 …N Jia, Z Shen, S Zhao, Y Wang, C Pei, D Huang… - International …, 2023 - Elsevier… The rats were placed in a hypobaric hypoxia chamber (ProOx-830, Tow-Int Tech, Shanghai,China) to mimic the environment of high-altitude hypobaric hypoxic. After the rats were …

[18]Nan Jia, Zherui Shen, Sijing Zhao, Yilan Wang, Caixia Pei, Demei Huang, Xiaomin Wang, Yongcan Wu, Shihua Shi, Yacong He, Zhenxing Wang,Eleutheroside E from pre-treatment of Acanthopanax senticosus (Rupr.etMaxim.) Harms ameliorates high-altitude-induced heart injury by regulating NLRP3 inflammasome-mediated pyroptosis via NLRP3/caspase-1 pathway,International Immunopharmacology,Volume 121,2023,110423,ISSN 1567-5769

[19]AUTHOR=Long Yanrong, Chen Hongbin, Deng Junchao, Ning Junjie, Yang Pengbo, Qiao Lina, Cao Zhongwei ，TITLE=Deficiency of endothelial FGFR1 alleviates hyperoxia-induced bronchopulmonary dysplasia in neonatal mice ，JOURNAL=Frontiers in Pharmacology VOLUME=13 YEAR=2022  DOI=10.3389/fphar.2022.1039103 ，The chamber contained a continuous oxygen monitoring system (ProOX-100HE, TOW-INTTECH) 

[20]Haimei Lun, Ruochuan Liu, Qiao Hu, Yaoli Liu, Lisi Wei, Xia Liu, Dan Wu, Shangyong Zhu,Contrast?Enhanced?Ultrasonography?of?Kidney?in?Chronic?Intermittent?Hypoxia?Rat?Model,[J]Journal of Ultrasound in Medicine,2022-12-07 ,DOI:10.1002/jum.16147