動物實驗低壓氧艙用于模擬低壓氧環(huán)境，氧氣濃度可自動控制，解決了艙體內(nèi)氧濃度的自動控制問題，同時氣體濃度在艙體內(nèi)更均勻，適用于中小型動物如犬、猴、兔、鼠等。

由動物艙體、氣體輸送控制系統(tǒng)、環(huán)境監(jiān)測系統(tǒng)、視頻監(jiān)測功能、溫控系統(tǒng)等構(gòu)成。通過調(diào)節(jié)動物艙內(nèi)氧氣（或空氣）和氮氣的混合比例，間接控制氧氣濃度的效果；氧氣濃度的大小以及維持低氧環(huán)境的時間，均由中央處理器自動控制，設(shè)備的自動化程度高，無須專人守候；流量計、分布器以及緩沖罐的使用，減小甚至消除了細(xì)股急流氣體對小動物的影響，具有供氣均勻、平緩的優(yōu)點，從源頭上消除了動物艙氧濃度分布不均勻的現(xiàn)象。

功能及特點

1.確保安全

從設(shè)計開始到zui終完成測試和檢查，所有實驗氧艙都遵循嚴(yán)格的生產(chǎn)過程；

具有緊急關(guān)閉和自動排氣系統(tǒng)，以適應(yīng)各種情況。

2.動物艙體

ProOx-810 動物實驗低壓氧艙主體采用進(jìn)口亞克力加厚材質(zhì)，堅固可靠，透明方便觀察；

鋁合金及不銹鋼材料支撐；

具有腳輪腳剎設(shè)計，方便移動。

3.氣體輸送控制系統(tǒng)

醫(yī)用級靜音高壓泵及低壓泵，為系統(tǒng)提供穩(wěn)定的壓力；

4.整體管路采用防爆管，抗壓強；

具有氣體緩沖器，減小甚至消除了細(xì)股急流氣體對小動物的影響；

多級空氣過濾器確保空氣來源清潔，消除碳?xì)浠衔锟赡芤鸬幕馂?zāi)危險；同時去除空氣供應(yīng)中的微粒物質(zhì)、水分、油和油蒸氣。

5.自動控制氧濃度及維持氧濃度的持續(xù)時間。

實驗監(jiān)測、控制、報警

監(jiān)測參數(shù)：艙體內(nèi)溫度、濕度、壓力、氧氣濃度、二氧化碳濃度監(jiān)測

控制參數(shù)：艙體內(nèi)的溫度、濕度、壓力、氧氣濃度、氧濃度維持時間

報警參數(shù)：溫度上限、溫度下限、壓力上限、壓力下限、氧濃度上限、氧濃度下限

6.動物生理指標(biāo)監(jiān)測

監(jiān)測指標(biāo)（選配）：心電圖、體溫、血壓、呼吸、血氧飽和度

具有擴展接口，用于靜脈注射、采血、血壓監(jiān)測等

7.視頻監(jiān)測功能

配備視頻采集卡及攝像頭，可錄像拍照

8.溫控系統(tǒng)

具有動物恒溫平臺，溫度可控制

采用水循環(huán)恒溫機制，防止電加熱過程在高氧環(huán)境中潛在的危險

使用客戶名單

相關(guān)文獻(xiàn)

[1]Ma Jinqiu,Wang Chenyun,Sun Yunbo,Pang Lulu,Zhu Siqing,Liu Yijing,Zhu Lin,Zhang Shouguo,Wang Lin,Du Lina. Comparative study of oral and intranasal puerarin for prevention of brain injury induced by acute high-altitude hypoxia.[J] International Journal of Pharmaceutics,2020,591

?[2]Guijuan Chen,Kang Cheng,Yun Niu,Li Zhu,Xueting Wang.Epicatechin gallate prevents inflammatory response in hypoxia-activated microglia and cerebral edema by inhibiting NF-κB signaling.[J]Archives of Biochemistry and Biophysics ,Volume 729, 109393;

[3]Yapeng,LuPanpanChang,WangwangDing,JiangpeiBian,DanWang,XuetingWang,QianqianLuo,XiaomeiWu,LiZhu.Pharmacological inhibition of mitochondrial division attenuates simulated high-altitude exposure-induced cerebral edema in mice: Involvement of inhibition of the NF-κB signaling pathway in glial cells.[J] European Journal of Pharmacology,Volume 929,2022,175137

[4]Jun-Yu Wei, Miao-Yue Hu, Xiu-Qi Chen, Feng-Ying Lei, Jin-Shuang Wei, Jie Chen, Xuan-Kai Qin & Yuan-Han Qin .Rosiglitazone attenuates hypoxia-induced renal cell apoptosis by inhibiting NF-κB signaling pathway in a PPARγ-dependent manner, [J] European Journal of Pharmacology,Renal Failure, 44:1, 2056-2065

[5]Yilan Wang, Zherui Shen, Caixia Pei, Sijing Zhao, Nan Jia, Demei Huang, Xiaomin Wang, Yongcan Wu, Shihua Shi, Yacong He, Zhenxing Wang,Eleutheroside B ameliorated high altitude pulmonary edema by attenuating ferroptosis and necroptosis through Nrf2-antioxidant response signaling, [J] Biomedicine & Pharmacotherapy, Volume 156, 2022,113982

[6]Fang Zhao, Yan Meng, Yue Wang, Siqi Fan, Yu Liu,Xiangfeng Zhang, Chenyang Ran, Hongxin Wang and Meili Lu,Protective effect of Astragaloside IV on chronic intermittent hypoxia-induced vascular endothelial dysfunction through the calpain-1/SIRT1/AMPK signaling pathway.[J] Frontiers in Pharmacology,10.3389/fphar.2022.920977

[7]Jing Zhang , Jian-Zhong Jiang , Jun Xu , Chen-Yu Xu , Shan Mao , Ying Shi , Wei Gu , Chun-Fang Zou , Yue-Ming Zhao , Liang Ye."Identification of Novel Biomarkers for Abdominal Aortic Aneurysm Promoted by Obstructive Sleep Apnea"[J]Annals of Vascular Surgery, Available online 2 February 2023

[8]Zhang, C., Sun, Y., Guo, Y. et al. “JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension. “[J].Cell Death Discov. 9, 98 (2023).

[9]Zhang, L., Liu, X., Wei, Q. et al. “Arginine attenuates chronic mountain sickness in rats via microRNA-144-5p. “[J]. Mamm Genome 34, 76–89 (2023).

[10]Yanhong Pei a b, Lifei Huang c, Tong Wang c, Qinhan Yao a, Yanrong Sun a, Yan Zhang a, Xiaomei Yang a, Jiliang Zhai d, Lihua Qin a, Jiajia Xue c, Xing Wang c, Hongquan Zhang a b, Junhao Yan."Bone marrow mesenchymal stem cells loaded into hydrogel/nanofiber composite scaffolds ameliorate ischemic brain injury. materialstoday ADVANCES, Volume 17, March 2023, 100349.

[11]Ma Jinqiu,Wang Chenyun,Sun Yunbo,Pang Lulu,Zhu Siqing,Liu Yijing,Zhu Lin,Zhang Shouguo,Wang Lin,Du Lina. "Comparative study of oral and intranasal puerarin for prevention of brain injury induced by acute high-altitude hypoxia" . [J] International Journal of Pharmaceutics,2020,591

[12]Jun-Yu Wei, Miao-Yue Hu, Xiu-Qi Chen, Feng-Ying Lei, Jin-Shuang Wei, Jie Chen, Xuan-Kai Qin & Yuan-Han Qin ."Rosiglitazone attenuates hypoxia-induced renal cell apoptosis by inhibiting NF-κB signaling pathway in a PPARγ-dependent manner" . [J]. European Journal of Pharmacology,Renal Failure, 44:1, 2056-2065

[13]Yilan Wang, Zherui Shen, Caixia Pei, Sijing Zhao, Nan Jia, Demei Huang, Xiaomin Wang, Yongcan Wu, Shihua Shi, Yacong He, Zhenxing Wang,"Eleutheroside B ameliorated high altitude pulmonary edema by attenuating ferroptosis and necroptosis through Nrf2-antioxidant response signaling" . [J]. Biomedicine & Pharmacotherapy, Volume 156, 2022,113982

[14]Yanfei Zhang, Jinyu Fang, Yingyue Dong, Huiru Ding, Quancheng Cheng, Huaicun Liu, Guoheng Xu, Weiguang Zhang“High-Altitude Hypoxia Exposure Induces Iron Overload and Ferroptosis in Adipose Tissue." [J]. Antioxidants 2022, 11, 2367.

[15]Wan-ping Yang, Mei-qi Li, Jie Ding, Jia-yan Li, Gang Wu, Bao Liu, Yu-qi Gao, Guo-hua Wang, Qian-qian Luo. "High-altitude hypoxia exposure inhibits erythrophagocytosis by inducing macrophage ferroptosis in the spleen." [J]. bioRxiv preprint, 2023.03.23.533972

[16]Xueting Wang, Yuqi Xie, Yun Niu, Baolan Wan, Yapeng Lu, Qianqian Luo, Li Zhu.CX3CL1/CX3CR1 signal mediates M1-type microglia and accelerates high-altitude-induced forgetting[J].2023-05-10 ,DOI:10.3389/fncel.2023.1189348

[17]Liu,J,Peng, S,Ye,L, Sun, Y, Zhao, Q, Wei, H, Luo, Q, He M, & Wang, G(2023).“ Neuroinflammation aggravated by traumatic brain injury at high altitude is reversed by L-serine via NFAT1-mediated microglial polarization."[J]. Frontiers in Cellular Neuroscience, 17, 1152392. doi: 10.3389/fncel.2023.1152392

[18]Ru Zhang,Ailin Yang,Lin Zhang,Linjie He,Xiaoming Gu,Caiyong Yu,Zhenxing Lu,Chuang Wang, Feng Zhou,Fei Li,Lele Ji,Jinliang Xing,Haitao Guo."MFN2 deficiency promotes cardiac response to hypobaric hypoxia by reprogramming cardiomyocyte metabolism."[J]. WILEY Online Library,2023-07-04 DOI: 10.1111/apha.14018

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